2-(5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-N-(2-methoxy-phenyl )-butyramide
SW044248
CAS: 522650-83-5
Molecular Formula: C22H23N5O2S
2-(5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-N-(2-methoxy-phenyl )-butyramide - Names and Identifiers
2-(5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-N-(2-methoxy-phenyl )-butyramide - Physico-chemical Properties
| Molecular Formula | C22H23N5O2S |
| Molar Mass | 421.52 |
| Solubility | DMSO: ≥ 30 mg/mL |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | 2-8°C |
| In vitro study | SW044248 is a non-canonical Top1 inhibitor, and is selectively toxic for certain NSCLC cell lines. SW044248 shows no effect on Top2. SW044248 (2, 5, 10 μM) rapidly inhibits transcription, translation and DNA synthesis in sensitive cells (HCC4017 and H292 cells) but not insensitive cells (HBEC30KT cells and HCC44 cells). SW044248 (10 μM) rapidly activates the integrated stress response through kinases GCN2 and PKR. The inhibition of Top1 in HCC4017 cells is helpful to the toxicity of SW044248. SW044248 (5, 10 μM) shows no effect on HBEC30KT and HCC44 cell lines due to the up-regulation of p21 CDKN1A . SW044248 is selectively toxic in 18/74 NSCLC lines. |
2-(5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-N-(2-methoxy-phenyl )-butyramide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.372 ml | 11.862 ml | 23.724 ml |
| 5 mM | 0.474 ml | 2.372 ml | 4.745 ml |
| 10 mM | 0.237 ml | 1.186 ml | 2.372 ml |
| 5 mM | 0.047 ml | 0.237 ml | 0.474 ml |
Last Update：2024-01-02 23:10:35
2-(5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-N-(2-methoxy-phenyl )-butyramide - Reference Information
| biological activity | SW-044248 is a non-classical Topo1 inhibitor, which has a selective toxic effect on non-small cell lung cancer cells. |
| target | TargetValue Topo1 () |
| Target | Value |
| in vitro study | SW044248 is a non-canonical Top1 inhibitor, and is selectively toxic for certain NSCLC cell lines. SW044248 shows no effect on Top2. SW044248 (2,5, 10 μ m) rapidly inhibits transcription, translation and DNA synthesis in sensitive cells (HCC4017 and H292 cells) but not insensitive cells (HBEC30KT cells and HCC44 cells). SW044248 (10 μM) rapidly activates the integrated stress response through kinases GCN2 and PKR. The inhibition of Top1 in HCC4017 cells is helpful to the toxicity of SW044248. SW044248 (5,10 μM) shows no effect on HBEC30KT and HCC44 cell lines due to the up-regulation of p21 CDKN1A . SW044248 is selectively toxic in 18/74 NSCLC lines. |
Last Update：2024-04-09 15:16:39
![2-(5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-N-(2-methoxy-phenyl )-butyramide](http://res.chembk.com/assets/images/structure/HY-19637.gif)
Supplier List
Featured ProductsSpot supply
Product Name: SW-044248 Visit Supplier Webpage Request for quotationCAS: 522650-83-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: SW044248 Visit Supplier Webpage Request for quotationCAS: 522650-83-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: SW044248 Visit Supplier Webpage Request for quotationCAS: 522650-83-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: SW044248 Visit Supplier Webpage Request for quotationCAS: 522650-83-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: SW-044248 Visit Supplier Webpage Request for quotationCAS: 522650-83-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: SW044248 Visit Supplier Webpage Request for quotationCAS: 522650-83-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: SW044248 Visit Supplier Webpage Request for quotationCAS: 522650-83-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: SW044248 Visit Supplier Webpage Request for quotationCAS: 522650-83-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
2-(5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-N-(2-methoxy-phenyl )-butyramide
494195-10-7
1H-Indole-3-carboxylic acid, 1-(4-quinolinyl)-
metylocykloheksanol(polish)
AURORA 128
2-[(Phenyl)amino]-3,5,6-trifluoro-2,5-cyclohexadiene-1,4-dione
3480-51-1
2-propenoicacid,2-methyl-,3,3,4,4,5,5,6,6,6-nonafluorohexylester
3-[(Allylthio)methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
1056113-44-0
494195-10-7
1H-Indole-3-carboxylic acid, 1-(4-quinolinyl)-
metylocykloheksanol(polish)
AURORA 128
2-[(Phenyl)amino]-3,5,6-trifluoro-2,5-cyclohexadiene-1,4-dione
3480-51-1
2-propenoicacid,2-methyl-,3,3,4,4,5,5,6,6,6-nonafluorohexylester
3-[(Allylthio)methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
1056113-44-0